San Francisco 49ers: 2022 NFL Schedule
Below you will find the weekly regular-season schedule for the San Francisco 49ers.
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| Week | Date | Opponent | Results |
|---|---|---|---|
| Week 1 | Sun., Sept. 11 | at Chicago Bears | L 10-19 |
| Week 2 | Sun., Sept. 18 | vs. Seattle Seahawks | W 27-7 |
| Week 3 | Sun., Sept. 25 | at Denver Broncos | L 10-11 |
| Week 4 | Mon., Oct. 3 | vs. Los Angeles Rams | W 24-9 |
| Week 5 | Sun., Oct. 9 | at Carolina Panthers | W 37-15 |
| Week 6 | Sun., Oct. 16 | at Atlanta Falcons | L 14-28 |
| Week 7 | Sun., Oct. 23 | vs. Kansas City Chiefs | L 23-44 |
| Week 8 | Sun., Oct. 30 | at Los Angeles Rams | W 31-14 |
| Week 9 | BYE | ||
| Week 10 | Sun., Nov. 13 | vs. Los Angeles Chargers | W 22-16 |
| Week 11 | Mon., Nov. 21 | at Arizona Cardinals | W 38-10 |
| Week 12 | Sun., Nov. 27 | vs. New Orleans Saints | W 13-0 |
| Week 13 | Sun., Dec. 4 | vs. Miami Dolphins | W 33-17 |
| Week 14 | Sun., Dec. 11 | vs. Tampa Bay Buccaneers | W 35-7 |
| Week 15 | Thu., Dec. 15 | at Seattle Seahawks | W 21-13 |
| Week 16 | Sat. Dec. 24 | vs. Washington Commanders | W 37-20 |
| Week 17 | Sun., Jan. 1 | at Las Vegas Raiders | W 37-34 (OT) |
| Week 18 | Sun., Jan. 8 | vs. Arizona Cardinals | W 38-13 |
Past San Francisco 49ers results: 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015
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