2025 NFL Draft - Oregon IDL Derrick Harmon

Buffalo needs an infusion on the interior of its defensive line, and Derrick Harmon has plenty of admirers. I find his tape to be inconsistent, but when he flashes, he flashes pretty bright.

The 49ers start to rebuild and reinforce their roster with a pick in the trenches. Harmon is equally adept at defending the run and pass, and can be asked to fill a variety of roles along the interior. He would be great in the 49ers' heavy use of twists and stunts, and he gives San Francisco a young player to start replenishing its recently tenacious front.

The 49ers wanted to trade down in this scenario, but the two most likely reasons for doing so — Warren and Jeanty — were off the board and the phone lines were dead. So San Francisco goes with Harmon, a big, productive defender with versatility on the inside of the line. No college interior defensive lineman had more quarterback pressures than Harmon last season, per PFF. The 49ers also have had good luck over the years with Ducks defenders — Arik Armstead, DeForest Buckner and Deommodore Lenoir. It's worth noting that GM John Lynch was among five 49ers scouts on hand for Oregon's pro day earlier this week and that he had dinner with Ducks head coach Dan Lanning. "He's become a good friend and ally," Lynch said Wednesday. — Matt Barrows