Ultimately, the decision of which player to start is largely determined by the composition of your roster (as well as your league's settings).
As an example, Charles Sims is listed below as a "start" for Week 3. And I'd feel comfortable going into Week 3 with him as one of my starting running backs.
That said, he may be a sit for your team.
In other words, if you owned C.J. Anderson, Matt Forte and Sims, you should start CJA and Forte -- and in turn, bench Sims.
So while you won't find absolute start-sit recommendations below (use my Week 3 Fantasy Football Rankings for that instead), the goal here is to highlight some players that I like (and would feel comfortable starting) as well as some players that I dislike for this week (and would prefer to keep on my bench).
With that said, here are some players to potentially start in Week 3:
RB - Melvin Gordon, San Diego Chargers (at IND)
His rookie season was a year to forget as Gordon averaged a pedestrian 3.48 yards per carry with zero touchdowns on 217 touches. Things are off to a much better start for the sophomore back. Rushing for a career-high 102 yards last week, MG3 scored his third touchdown of this young season. Finishing as a top-10 fantasy running back in both games, Gordon has scored the fourth-most fantasy points among running backs through Week 2.
With Danny Woodhead (ACL) out for the season, MG3 had a total of 27 touches in Sunday's rout of the Jaguars. Given the team's injuries on offense, Gordon should be a lock for a massive workload each and every week. Two weeks into the season, the Colts have already allowed a trio of top-10 fantasy running backs and no team has allowed more fantasy points to opposing running backs.
- Related: Gordon is my Favorite Play on DraftKings in Week 3
RB - Frank Gore, Indianapolis Colts (vs. SD)
The other running back in this game has upside as an RB2 this week as well. With the 20th-most fantasy points through two weeks, Gore is averaging only 3.81 YPC but he has at least 16 touches in each game. Only seven teams allow more fantasy points to the position this season than the Chargers, who allowed the fourth-most to opposing running backs last season. As home favorites, Gore and the Colts are projected to score the third-most points this week based on Vegas odds.
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RB - Charles Sims, Tampa Bay Buccaneers (vs. LA)
As a change-of-pace option to Doug Martin last season, Sims finished as fantasy's RB22 (RB17 in PPR) in 2015. With Martin (hamstring) out this week (and expected to miss a few games), Sims will lead the backfield in usage over the next few weeks. Among running backs that ranked inside the top-40 running backs last season, no running back averaged more yards per touch (6.90) than Sims. Favored by 5.5 points at home against the low-powered Rams, Sims could benefit from positive game flow, but his receiving prowess should keep him on the field regardless of the score.
RB - DeMarco Murray, Tennessee Titans (vs. OAK)
Through two weeks, Murray has the eighth-most fantasy points (RB4 in PPR) with 222 yards from scrimmage, an RB-high (tied with T.J. Yeldon) 12 receptions and two touchdowns. While their pass defense has been lit up by Drew Brees and Matt Ryan, the Titans will likely rely on a ground-and-pound game plan with Murray and rookie Derrick Henry and should have plenty of success. Allowing an average of 517.5 yards and 34.5 points per game, the Raiders have allowed 4.40 YPC (eighth-most) to opposing running backs so far this season.
RB - Christine Michael, Seattle Seahawks (vs. SF)
Through two weeks, Michael has 25 carries for 126 yards (5.04 YPC) and five receptions for 31 yards. With Thomas Rawls out this week, the Seahawks will rely on Michael as their lead back. Nearly double-digit favorites, positive game flow should lead to a heavy workload (and perhaps multiple scoring opportunties) for C-Mike. Coach Pete Carroll said (via the Seattle Times): "He’s had 20-something carries so far. He’s ready to carry the ball 20-something times in a game. He could be fine with that."
Here are some players to potentially sit in Week 3:
RB - Jerick McKinnon, Minnesota Vikings (at CAR)
The Star Tribune's Matt Vensel has projected that McKinnon could handle the "65" part of a 65/35 split with Matt Asiata in Adrian Peterson's absence. Most of McKinnon's yardage will likely come between the 20's, however, as the team seems to trust Asiata more in the red zone. In fact, Asiata has a league-high three games with three-plus rushing scores since 2013. While I'd prefer not to use McKinnon or Asiata as my RB2, both are in the flex mix for me.
RB - T.J. Yeldon, Jacksonville Jaguars (vs. BAL)
The good news is that Yeldon had a total of 40 touches in Weeks 1 and 2 as Chris Ivory was a scratch. The bad news for Yeldon fantasy owners is that he generated an inefficient 107 YFS on those touches -- 21/39 rushing (1.86 YPC) in Week 1 and 8/10 receiving (1.25 Y/R) in Week 2. Due to his passing-game volume, Yeldon finished as the RB18 in PPR last week despite finishing as the RB46 in standard-scoring formats. With Ivory due to make his Jacksonville debut this week, Yeldon (and Ivory) should remain on your bench.
RB - Carlos Hyde, San Francisco 49ers (at SEA)
Productive in the opener, Hyde had 25 touches and scored two touchdowns as he finished as fantasy's RB5, but he managed only 3.83 YPC in Week 1. Even less efficient in Week 2 against the Panthers, Hyde averaged just 2.43 YPC and he also lost a fumble.
Things won't get any easier in Week 3 as the 49ers head north to Seattle. Only the Packers (1.84) and Vikings (2.65) have allowed fewer yards per carry to opposing running backs than the Seahawks (2.86) this season.
Facing a tough Seahawks defense, no team is projected to score fewer points than the 49ers this week based on Vegas odds. Nearly double-digit underdogs, game flow could limit Hyde's opportunities if the 49ers get down early, as expected.
RB - Matt Jones, Washington Redskins (at NYG)
Jones had 13 carries for 61 yards and a touchdown last week against Dallas as he scored the 14th-most fantasy points among running backs in Week 2. That said, the matchup isn't great for Jones in Week 3 as a road underdog against a revamped Giants defense. Not only have the Giants allowed the sixth-fewest fantasy points to opposing running backs, but they have allowed only 3.18 YPC to opposing backs as well.
- More Fantasy Football Start'em, Sit'em for Week 3
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